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.Friday, May 29, 2009


In a controversial achievement, Japanese scientists announced on Wednesday they had created the world's first transgenic primates, breeding monkeys with a gene that made the animals' skin glow a fluorescent green.The exploit opens up exciting prospects for medical researchers, they said.
It could eventually lead to lab monkeys that replicate some of humanity's most devastating diseases, providing a new model for exploring how these disorders are caused and how they may be cured.
"Great advances in pre-clinical research can be expected using these models," the team said.
But other voices warned of a potential ethics storm, brewed by fears that technology used on our closest animal relatives could be turned to create genetically-engineered humans.
In a study published in the British journal Nature, a team led by Erika Sasaki of the Central Institute for Experimental Animals at Keio University reported on experiments on common marmosets (Callithrix jacchus), a small monkey native to Brazil.
They introduced a foreign gene, tucked inside a virus, into marmoset embryos that were then nurtured in a bath of sucrose.
The gene codes for green fluorescent protein (GFP), a substance that was originally isolated from a jellyfish and is now commonly used as a biotech marker. An animal tagged with GFP glows green when exposed to ultraviolet light, proving that a key gene sequence has been switched on.
The transgenic embryos were then implanted in the uterus of seven surrogate mother marmosets.
Three of recipients miscarried. The other four gave birth to five offspring, all of which carried the GFP gene.
In two of these five, the GFP gene had been incorporated into the reproductive cells. A second generation of marmosets was then derived from one of the two.
The work is important, because medical researchers have hankered for an animal model that is closer to the human anatomy than rodents.
Mice and rats, genetically engineered to have the symptoms of certain human diseases, are the mainstay of pre-clinical lab work, in which scientists test their theories before trying out any outcome on human volunteers.
But many disorders, especially neurological diseases such as Alzheimer's and Parkinson's, are so complex that they cannot be reproduced meaningfully in rodents because their biology is different.
Hopes for a non-human primate model have until now been dashed by the failure to insert a gene into a monkey's sperm and eggs -- the "germline" that ensures that the inserted DNA is passed on to future generations rather than lost.
The first genetically-modified monkey was born in 2000. Known as ANDi (the initials of "Inserted DNA," spelt backwards), the rhesus carried the GFP gene but not in its reproductive cells.
The latest exploit thus opens up hopes of eventually breeding colonies of transgenic primates with inherited traits that closely replicate human disease.
"This is the first case ever established in the world that an introduced gene was successfully inherited (by) the next generation in primates," the researchers said in a press relase.
Future plans include creating transgenic marmosets that replicate human diseases such as Parkinson's and amyotrophic lateral sclerosis.
In a commentary also published by Nature, Gerald Schatten and Shoukhrat Mitalipov, primate research specialists in the US, praised the achievement as "undoubtedly a milestone" but sounded caution.
They said marmosets were not as useful as baboons or rhesus monkeys in replicating some diseases, notably HIV and tuberculosis.
Another question was the random insertion of a foreign gene in the monkey's genetic code. This may have caused some of the miscarriages and, if previous research is a guide, could unleash cancer.
Scientists also have to address legitimate public concern about animal welfare and the need for "realistic policies" to prevent genetically-engineered babies, they warned.
"There are many unanswered questions," Helen Wallace, of GeneWatch UK, a British NGO that monitors the ethics of gene research, told AFP.
"It's a big step from making a fluorescent green marmoset to making a marmoset that replicates a human disease, it's a much more complicated thing to do.
"There's also a very important ethical debate, firstly about the animals themselves and secondly about what this might lead to in the future, whether it might be ethically justified to genetically engineer humans."

Human really is something that need to be destory.
Creating lot of new thing that will harm the environment.
and try to make new animal by mix two different animal.
sad for the monkey.


Memory of U & mi stop @ 3:31 PM

.Wednesday, May 20, 2009


蔡依林- 妥協




蔡依林- 妥協 Lyric


你总爱编织谎言

我负责配合表演

所有改变

只为了进入你的世界

这情节 重复了一百遍

才发现 是你的心太远

你划定楚河汉界

我不敢请你犯规

所有时间

都是先给了你优先权

不自觉 爱到不敢冒险

成了你的傀儡一年两年

才看见我有多狼狈

爱到妥协 到头来还视无见

抱着你 不让你背

于是不断重演 我好累

爱到妥协 犹豫抱歉不时在出现

越想退后一点

我躲在我的世界

你只是害怕一个人睡

我不想在为你掉泪

我了解 不会再仍在徘徊

开始自己的明天


Memory of U & mi stop @ 10:10 PM

.Monday, May 18, 2009


Show Luo, badly affected by the recent "online dating scandal", got emotional and cried when he was hosting a variety show on Wednesday.

After a Hong Kong netizen named "Fanny" exposed her online relationship with the celebrity, three other female models also claimed that the latter had taken the initiative in befriending them, resulting in a series of reports that portrayed Luo as an "online player".

Agitated by the scandal, Luo broke down when he spoke of this scandal on the variety show he was hosting.
According to him, he was just making friends sincerely and did not understand why he was portrayed as a "player".

The Taiwanese media reported the scandal at great length and netizens criticized him for creating an illusive healthy image as a fae of his true self.

Luo has denied all accusations.
"I am who I am.

I tell jokes and sometimes dirty ones but all just for show effect."
Luo described himself as a tenacious cockroach that will never be defeated.

"I am a cockroach, never beaten. If someone is out to bring me down, I'll have to apologize to you. You can't do it. I am unbeatable."
This was seen as a provocative statement targeted at the media, Luo's manager clarified that the artiste was just annoyed with the media for magnifying the most insignificant matters.

He was overly depressed with the negative press but never meant to offend the reporters.


Memory of U & mi stop @ 9:28 PM

.Sunday, May 17, 2009

Recently read about Luo Zhi Xiang's News.
He was like a poor thing trying to make new friend,
but yet being betray by the girl.
He say he was sorry about what have happen.
But he just want to make friend.
Sad.
Another Reporter more fcuk up.
Luo Zhi Xiang is so poor thing already yet he go write more bad thing about him.
and what the reporter say is not true.
Poor thing.
Say about this thing until he cry.
He must be really hurt by this incident.
Please la.
He JUST WANT TO MAKE FRIEND.
Why say until he like a pervert.
Poor Luo Zhi Xiang.
Nevermind man.
I believe all your fan will know how you feel and still support you till the end.
Sing more nice song.
I really like you song.


Memory of U & mi stop @ 11:56 PM

.Friday, May 15, 2009


張芸京-黑裙子



Memory of U & mi stop @ 1:57 PM

.Friday, May 08, 2009


我知道



Memory of U & mi stop @ 3:13 PM